Research Article
Metamfetamin kullanım bozukluğunda beyin hacmi ölçümlerinin volbrain yöntemi kullanılarak sağlıklı bireylerle karşılaştırılması
Abstract
Amaç: Bu çalışmanın amacı, metamfetamin kullanım bozukluğu (MKB) olan bireylerde beyin yapılarını incelemek ve metamfetaminin bu yapılar üzerindeki olası etkilerini anlamaktır.
Gereç ve Yöntem: Çalışmada 21 MKB ve 21 sağlıklı kontrol retrospektif olarak değerlendirildi. VolBrain segmentasyon yöntemi kullanıldı.
Bulgular: Substantia grisea (SG), kortikal SG serebrum total ve SG hacimleri sağlıklı kontrol grubuna kıyasla daha az ve anlamlı bulunmuştur (p<0,01). Accumbens, pars basalis telencephali, lobus caudatus, globus pallidus, putamen ve lobus parietalis hacimleri MKB’de artmıştır (p<0,01). Amygdala, hippocampus, ventral diensefalon, lobus frontalis, gyrus orbitalis posterior, gyrus precentralis, lobus temporalis, calcarine cortex, gyrus occipitalis medium, gyrus occipitalis superior, lobus limbicus hacimleri MKB’de sağlıklı kontrollere kıyasla anlamlı derecede küçüktü.
Sonuç: Bu çalışma, MKB’nin beyin yapıları üzerindeki etkilerini daha iyi anlamamıza yardımcı oldu. Ayrıca, MKB tedavisi ve önlenmesi için etkili stratejiler geliştirmek için önemli bilgiler sağlamıştır.
Keywords
Ethical Statement
Ataturk University Faculty of Medicine Clinical Research Ethics Committee with the ethics committee decision numbered B.30.2.ATA.0.01.00/128 and dated 26.01.2023. This study conformed to the Helsinki Declaration.
Supporting Institution
There is no person/organization that financially supports this study.
References
- Jayanthi S, Daiwile AP, Cadet JL. Neurotoxicity of methamphetamine: Main effects and mechanisms. Experimental neurology. 2021;344:113795.
- Prakash MD, Tangalakis K, Antonipillai J, Stojanovska L, Nurgali K, Apostolopoulos V. Methamphetamine: effects on the brain, gut and immune system. Pharmacological research. 2017;120:60-67.
- Pauly RC, Bhimani RV, Li J-X, Blough BE, Landavazo A, Park J. Distinct Effects of Methamphetamine Isomers on Limbic Norepinephrine and Dopamine Transmission in the Rat Brain. ACS Chemical Neuroscience. 2023.
- Jia X, Wang J, Jiang W, et al. Common gray matter loss in the frontal cortex in patients with methamphetamine-associated psychosis and schizophrenia. NeuroImage: Clinical. 2022;36:103259.
- Nie L, Ghahremani DG, Mandelkern MA, et al. The relationship between duration of abstinence and gray-matter brain structure in chronic methamphetamine users. The American Journal of Drug and Alcohol Abuse. 2021;47(1):65-73.
- MacDuffie KE, Brown GG, McKenna BS, et al. Effects of HIV Infection, methamphetamine dependence and age on cortical thickness, area and volume. NeuroImage: Clinical. 2018;20:1044-1052.
- Hall MG, Alhassoon OM, Stern MJ, et al. Gray matter abnormalities in cocaine versus methamphetamine-dependent patients: a neuroimaging meta-analysis. The American journal of drug and alcohol abuse. 2015;41(4):290-299.
- Mackey S, Paulus M. Are there volumetric brain differences associated with the use of cocaine and amphetamine-type stimulants? Neuroscience & Biobehavioral Reviews. 2013;37(3):300-316.
- Nakama H, Chang L, Fein G, Shimotsu R, Jiang CS, Ernst T. Methamphetamine users show greater than normal age‐related cortical gray matter loss. Addiction. 2011;106(8):1474-1483.
- Koester P, Tittgemeyer M, Wagner D, Becker B, Gouzoulis-Mayfrank E, Daumann J. Cortical thinning in amphetamine-type stimulant users. Neuroscience. 2012;221:182-192.
- Jernigan TL, Gamst AC, Archibald SL, et al. Effects of methamphetamine dependence and HIV infection on cerebral morphology. American Journal of Psychiatry. 2005;162(8):1461-1472.
- Thompson PM, Hayashi KM, Simon SL, et al. Structural abnormalities in the brains of human subjects who use methamphetamine. Journal of Neuroscience. 2004;24(26):6028-6036.
- Avnioglu S, Sahin C, Cankaya S, et al. Decreased frontal and orbital volumes and increased cerebellar volumes in patients with anosmia Of Unknown origin: A subtle connection? Journal of Psychiatric Research. 2023;160:86-92.
- Acer N, Bastepe-Gray S, Sagiroglu A, et al. Diffusion tensor and volumetric magnetic resonance imaging findings in the brains of professional musicians. Journal of Chemical Neuroanatomy. 2018;88:33-40.
- Gülru E, Gürler Rr, Altunişik E, Şirik M, Özbağ D. Retrospective Investigation of Brainstem Volume and Craniovertebral Junction Morphometry in Migraine Patients. Medical Records.2023;5(2):262-268.
- Coupé P, Mansencal B, Clément M, et al. AssemblyNet: A large ensemble of CNNs for 3D whole brain MRI segmentation. NeuroImage. 2020;219:117026.
- Akkaya N, Aktürk İ, Yaman ÖM. Türkiye’de 2011-2021 Yılları Arasında Uçucu Nitelikli Maddelerin Kullanımına Yönelik İstatistiki Verilerin Değerlendirilmesi. Bağımlılık Dergisi. 2023;24(2):239-272.
- Scott JC, Woods SP, Matt GE, et al. Neurocognitive effects of methamphetamine: a critical review and meta-analysis. Neuropsychology review. 2007;17:275-297.
- Shrestha P, Katila N, Lee S, Seo JH, Jeong J-H, Yook S. Methamphetamine induced neurotoxic diseases, molecular mechanism, and current treatment strategies. Biomedicine & Pharmacotherapy. 2022;154:113591.
- Naji L, Dennis B, Rosic T, et al. Mirtazapine for the treatment of amphetamine and methamphetamine use disorder: A systematic review and meta-analysis. Drug and Alcohol Dependence. 2022;232:109295.
- Mizoguchi H, Yamada K. Methamphetamine use causes cognitive impairment and altered decision-making. Neurochemistry international. 2019;124:106-113.
- Shukla M, Vincent B. Methamphetamine abuse disturbs the dopaminergic system to impair hippocampal-based learning and memory: An overview of animal and human investigations. Neuroscience & Biobehavioral Reviews. 2021;131:541-559.
- Nie L, Zhao Z, Wen X, et al. " Gray-matter structure in long-term abstinent methamphetamine users": Author correction. 2021.
- Berman S, O'Neill J, Fears S, Bartzokis G, London ED. Abuse of amphetamines and structural abnormalities in the brain. Annals of the New York Academy of Sciences. 2008;1141(1):195-220.
- Eskandarian Boroujeni M, Peirouvi T, Shaerzadeh F, Ahmadiani A, Abdollahifar MA, Aliaghaei A. Differential gene expression and stereological analyses of the cerebellum following methamphetamine exposure. Addiction biology. 2020;25(1):e12707.
- Heidari Z, Mahmoudzadeh-Sagheb H, Shakiba M, Gorgich EAC. Stereological analysis of the brain in methamphetamine abusers compared to the controls. International Journal of High Risk Behaviors and Addiction. 2017;6(4).
- Golsorkhdan SA, Boroujeni ME, Aliaghaei A, et al. Methamphetamine administration impairs behavior, memory and underlying signaling pathways in the hippocampus. Behavioural Brain Research. 2020;379:112300.
- Recinto P, Samant ARH, Chavez G, et al. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology. 2012;37(5):1275-1287.
- Warton FL, Meintjes EM, Warton CM, et al. Prenatal methamphetamine exposure is associated with reduced subcortical volumes in neonates. Neurotoxicology and teratology. 2018;65:51-59.
- Orikabe L, Yamasue H, Inoue H, et al. Reduced amygdala and hippocampal volumes in patients with methamphetamine psychosis. Schizophrenia research. 2011;132(2-3):183-189.
- Jan RK, Lin JC, Miles SW, Kydd RR, Russell BR. Striatal volume increases in active methamphetamine-dependent individuals and correlation with cognitive performance. Brain sciences. 2012;2(4):553-572.
- Roos A, Jones G, Howells FM, Stein DJ, Donald KA. Structural brain changes in prenatal methamphetamine-exposed children. Metabolic Brain Disease. 2014;29:341-349.
- Lin JC, Jan RK, Kydd RR, Russell BR. Investigating the microstructural and neurochemical environment within the basal ganglia of current methamphetamine abusers. Drug and Alcohol Dependence. 2015;149:122-127.
- Aoki Y, Orikabe L, Takayanagi Y, et al. Volume reductions in frontopolar and left perisylvian cortices in methamphetamine induced psychosis. Schizophrenia research. 2013;147(2-3):355-361.
- Bartzokis G, Beckson M, Lu PH, et al. Age-related brain volume reductions in amphetamine and cocaine addicts and normal controls: implications for addiction research. Psychiatry Research: Neuroimaging. 2000;98(2):93-102
Comparison of brain volume measurements in methamphetamine use disorder with healthy individuals using volbrain method
Abstract
Aim: This study aims to examine brain structures in individuals with methamphetamine use disorder (MUD) and to understand the possible effects of methamphetamine on these structures.
Materials and Methods: The study was retrospectively evaluated in 21 MUD and 21 healthy controls. VolBrain segmentation method was used.
Results: Grey Matter (GM), Cortical GM, Cerebrum total, and GM volumes were found to be less and significantly higher in MUD compared to healthy controls (p<0.01). Accumbens, Basal Forebrain, Caudate, Pallidum, Putamen, and Parietal Lobe volumes were increased in MUD (p<0.01). Amygdala, Hippocampus, Ventral Diencephalone, Frontal Lobe, Posterior Orbital Gyrus, Precentral Gyrus, Temporal Lobe, Calcarine Cortex, Middle Occipital Gyrus, Superior Occipital Gyrus, Limbic Cortex volumes were significantly smaller in MUD compared to healthy controls.
Conclusion: This study helped us better understand MUD's effects on brain structures. It also provided important information for developing effective strategies for treating and preventing MUD.
Keywords
Ethical Statement
Ataturk University Faculty of Medicine Clinical Research Ethics Committee with the ethics committee decision numbered B.30.2.ATA.0.01.00/128 and dated 26.01.2023. This study conformed to the Helsinki Declaration.
Supporting Institution
There is no person/organization that financially supports this study.
References
- Jayanthi S, Daiwile AP, Cadet JL. Neurotoxicity of methamphetamine: Main effects and mechanisms. Experimental neurology. 2021;344:113795.
- Prakash MD, Tangalakis K, Antonipillai J, Stojanovska L, Nurgali K, Apostolopoulos V. Methamphetamine: effects on the brain, gut and immune system. Pharmacological research. 2017;120:60-67.
- Pauly RC, Bhimani RV, Li J-X, Blough BE, Landavazo A, Park J. Distinct Effects of Methamphetamine Isomers on Limbic Norepinephrine and Dopamine Transmission in the Rat Brain. ACS Chemical Neuroscience. 2023.
- Jia X, Wang J, Jiang W, et al. Common gray matter loss in the frontal cortex in patients with methamphetamine-associated psychosis and schizophrenia. NeuroImage: Clinical. 2022;36:103259.
- Nie L, Ghahremani DG, Mandelkern MA, et al. The relationship between duration of abstinence and gray-matter brain structure in chronic methamphetamine users. The American Journal of Drug and Alcohol Abuse. 2021;47(1):65-73.
- MacDuffie KE, Brown GG, McKenna BS, et al. Effects of HIV Infection, methamphetamine dependence and age on cortical thickness, area and volume. NeuroImage: Clinical. 2018;20:1044-1052.
- Hall MG, Alhassoon OM, Stern MJ, et al. Gray matter abnormalities in cocaine versus methamphetamine-dependent patients: a neuroimaging meta-analysis. The American journal of drug and alcohol abuse. 2015;41(4):290-299.
- Mackey S, Paulus M. Are there volumetric brain differences associated with the use of cocaine and amphetamine-type stimulants? Neuroscience & Biobehavioral Reviews. 2013;37(3):300-316.
- Nakama H, Chang L, Fein G, Shimotsu R, Jiang CS, Ernst T. Methamphetamine users show greater than normal age‐related cortical gray matter loss. Addiction. 2011;106(8):1474-1483.
- Koester P, Tittgemeyer M, Wagner D, Becker B, Gouzoulis-Mayfrank E, Daumann J. Cortical thinning in amphetamine-type stimulant users. Neuroscience. 2012;221:182-192.
- Jernigan TL, Gamst AC, Archibald SL, et al. Effects of methamphetamine dependence and HIV infection on cerebral morphology. American Journal of Psychiatry. 2005;162(8):1461-1472.
- Thompson PM, Hayashi KM, Simon SL, et al. Structural abnormalities in the brains of human subjects who use methamphetamine. Journal of Neuroscience. 2004;24(26):6028-6036.
- Avnioglu S, Sahin C, Cankaya S, et al. Decreased frontal and orbital volumes and increased cerebellar volumes in patients with anosmia Of Unknown origin: A subtle connection? Journal of Psychiatric Research. 2023;160:86-92.
- Acer N, Bastepe-Gray S, Sagiroglu A, et al. Diffusion tensor and volumetric magnetic resonance imaging findings in the brains of professional musicians. Journal of Chemical Neuroanatomy. 2018;88:33-40.
- Gülru E, Gürler Rr, Altunişik E, Şirik M, Özbağ D. Retrospective Investigation of Brainstem Volume and Craniovertebral Junction Morphometry in Migraine Patients. Medical Records.2023;5(2):262-268.
- Coupé P, Mansencal B, Clément M, et al. AssemblyNet: A large ensemble of CNNs for 3D whole brain MRI segmentation. NeuroImage. 2020;219:117026.
- Akkaya N, Aktürk İ, Yaman ÖM. Türkiye’de 2011-2021 Yılları Arasında Uçucu Nitelikli Maddelerin Kullanımına Yönelik İstatistiki Verilerin Değerlendirilmesi. Bağımlılık Dergisi. 2023;24(2):239-272.
- Scott JC, Woods SP, Matt GE, et al. Neurocognitive effects of methamphetamine: a critical review and meta-analysis. Neuropsychology review. 2007;17:275-297.
- Shrestha P, Katila N, Lee S, Seo JH, Jeong J-H, Yook S. Methamphetamine induced neurotoxic diseases, molecular mechanism, and current treatment strategies. Biomedicine & Pharmacotherapy. 2022;154:113591.
- Naji L, Dennis B, Rosic T, et al. Mirtazapine for the treatment of amphetamine and methamphetamine use disorder: A systematic review and meta-analysis. Drug and Alcohol Dependence. 2022;232:109295.
- Mizoguchi H, Yamada K. Methamphetamine use causes cognitive impairment and altered decision-making. Neurochemistry international. 2019;124:106-113.
- Shukla M, Vincent B. Methamphetamine abuse disturbs the dopaminergic system to impair hippocampal-based learning and memory: An overview of animal and human investigations. Neuroscience & Biobehavioral Reviews. 2021;131:541-559.
- Nie L, Zhao Z, Wen X, et al. " Gray-matter structure in long-term abstinent methamphetamine users": Author correction. 2021.
- Berman S, O'Neill J, Fears S, Bartzokis G, London ED. Abuse of amphetamines and structural abnormalities in the brain. Annals of the New York Academy of Sciences. 2008;1141(1):195-220.
- Eskandarian Boroujeni M, Peirouvi T, Shaerzadeh F, Ahmadiani A, Abdollahifar MA, Aliaghaei A. Differential gene expression and stereological analyses of the cerebellum following methamphetamine exposure. Addiction biology. 2020;25(1):e12707.
- Heidari Z, Mahmoudzadeh-Sagheb H, Shakiba M, Gorgich EAC. Stereological analysis of the brain in methamphetamine abusers compared to the controls. International Journal of High Risk Behaviors and Addiction. 2017;6(4).
- Golsorkhdan SA, Boroujeni ME, Aliaghaei A, et al. Methamphetamine administration impairs behavior, memory and underlying signaling pathways in the hippocampus. Behavioural Brain Research. 2020;379:112300.
- Recinto P, Samant ARH, Chavez G, et al. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology. 2012;37(5):1275-1287.
- Warton FL, Meintjes EM, Warton CM, et al. Prenatal methamphetamine exposure is associated with reduced subcortical volumes in neonates. Neurotoxicology and teratology. 2018;65:51-59.
- Orikabe L, Yamasue H, Inoue H, et al. Reduced amygdala and hippocampal volumes in patients with methamphetamine psychosis. Schizophrenia research. 2011;132(2-3):183-189.
- Jan RK, Lin JC, Miles SW, Kydd RR, Russell BR. Striatal volume increases in active methamphetamine-dependent individuals and correlation with cognitive performance. Brain sciences. 2012;2(4):553-572.
- Roos A, Jones G, Howells FM, Stein DJ, Donald KA. Structural brain changes in prenatal methamphetamine-exposed children. Metabolic Brain Disease. 2014;29:341-349.
- Lin JC, Jan RK, Kydd RR, Russell BR. Investigating the microstructural and neurochemical environment within the basal ganglia of current methamphetamine abusers. Drug and Alcohol Dependence. 2015;149:122-127.
- Aoki Y, Orikabe L, Takayanagi Y, et al. Volume reductions in frontopolar and left perisylvian cortices in methamphetamine induced psychosis. Schizophrenia research. 2013;147(2-3):355-361.
- Bartzokis G, Beckson M, Lu PH, et al. Age-related brain volume reductions in amphetamine and cocaine addicts and normal controls: implications for addiction research. Psychiatry Research: Neuroimaging. 2000;98(2):93-102
There are 35 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Central Nervous System |
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 31, 2023 |
| Submission Date | September 6, 2023 |
| Acceptance Date | November 19, 2023 |
| Published in Issue | Year 2023 Volume: 9 Issue: 3 |
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