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Year 2019, Volume: 5 Issue: 2, 36 - 39, 15.12.2019

Selçuk Çeker

Abstract

References

  • ALBAYRAK, S., AKSOY, A., SAGDIC, O., BUDAK, U. (2010), Phenolic compounds and antioxidant and antimicrobial properties of Helichrysum species collected from eastern Anatolia, Turkey, Turkish Journal of Biology; 34(4), 463-473.
  • ANDERSON, D., YU, T.W., PHILLIPS, B., SCHMEZER, P. (1994), The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; 307(1), 261-271.
  • ASLAN, M., ORHAN, D.D., ORHAN, N., SEZIK, E., YESILADA, E. (2007), In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. plicatum capitulums in streptozotocin-induced-diabetic rats, Journal of ethnopharmacology; 109(1), 54-59.
  • BAYIR, Y., HALICI, Z., KELES, M.S., COLAK, S., CAKIR, A., KAYA, Y., AKCAY, F. (2011), Helichrysum plicatum DC. subsp. plicatum extract as a preventive agent in experimentally induced urolithiasis model, Journal of ethnopharmacology; 138(2), 408-414.
  • BAYTOP, T. (1999), Türkiye'de bitkiler ile tedavi: geçmişte ve bugün, Nobel Tıp Kitabevleri.
  • BIGOVIĆ, D., ŠAVİKİN, K., JANKOVİĆ, T., MENKOVİĆ, N., ZDUNİĆ, G., STANOJKOVİĆ, T., DJURİĆ, Z. (2011), Antiradical and cytotoxic activity of different Helichrysum plicatum flower extracts, Natural product communications; 6(6), 1934578X1100600617.
  • COLLINS, A.R., AI-GUO M., DUTHIE, S.J. (1995), The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells, Mutation Research/DNA Repair; 336(1), 69-77.
  • DEMIREL, S., ZAMANI, A.G., (2002), Mikronükleus tekniği ve kullanım alanları, Genel Tıp Dergisi; 12(3),123-127.
  • EROGLU, H.E., AKSOY, A., HAMZAOGLU, E., BUDAK, U., ALBAYRAK, S. (2009), Cytogenetic effects of nine Helichrysum taxa in human lymphocytes culture, Cytotechnology; 59(1),65-72.
  • FENECH, M. (2000), The in vitro micronucleus technique, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; 455(1-2),81-95.
  • JENA, G., KAUL, C., RAMARAO, P. (2002), Genotoxicity testing, a regulatory requirement for drug discovery and development: impact of ICH guidelines, Indian journal of pharmacology; 34(2),86-99.
  • KOTAN, R., DADASOGLU, F., KORDALI, S., CAKIR, A., DIKBAS, N., CAKMAKCI, R. (2007), Antibacterial activity of essential oils extracted from some medicinal plants, carvacrol and thymol on Xanthomonas axonopodis pv. vesicatoria (Doidge) Dye causes bacterial spot disease on pepper and tomato, Journal of Agricultural Technology; 3(2), 299-306.
  • KULEVANOVA, S., STEFOVA, M., STAFILOV, T. (2000), HPLC identification and determination of flavone aglycones in Helichrysum plicatum DC.(Asteraceae), Die Pharmazie; 55(5),391.
  • KURTULMUS, S., AYDIN, A. (2007), Dental döküm alaşımlarının genotoksisite, mutajenisite ve karsinojenisitesi, Selçuk Üniversitesi Dişhekimliği Fakültesi Dergisi;16,73-78.
  • MEYER, J., AFOLAYAN, A., TAYLOR, M., ERASMUS, D. (1997), Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens, Journal of ethnopharmacology; 56(2),165-169.
  • ORHAN, F., CEKER, S., ANAR, M., AGAR, G., ARASOGLU, T., GULLUCE, M. (2016), Protective effects of three luteolin derivatives on aflatoxin B 1-induced genotoxicity on human blood cells, Medicinal chemistry research; 25(11), 2567-2577.
  • OZTURK, B., OZEK, G., OZEK, T., BASER, K.H.C. (2014), Chemical diversity in volatiles of Helichrysum plicatum DC. subspecies in Turkey, Records of Natural Products; 8(4), 373.
  • SCHINELLA, G., TOURNIER, H., PRIETO, J., DE BUSCHIAZZO, P.M., RIOS, J. (2002), Antioxidant activity of anti-inflammatory plant extracts, Life sciences;70(9),1023-1033.
  • SINGH, N.P., MCCOY, M.T., TICE, R.R., SCHNEIDER, E.L. (1988), A simple technique for quantitation of low levels of DNA damage in individual cells, Experimental cell research; 175(1),184-191.
  • TEPE, B., SOKMEN, M., AKPULAT, H.A., SOKMEN, A. (2005), In vitro antioxidant activities of the methanol extracts of four Helichrysum species from Turkey, Food Chemistry; 90(4), 685-689.
  • TICE, R.R., AGURELL, E., ANDERSON, D., BURLINSON, B., HARTMANN, A., KOBAYASHI, H., MIYAMAE, Y., ROJAS, E., RYU, J.C., SASAKI, Y. (2000), Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing, Environmental and molecular mutagenesis; 35(3), 206-221.
  • VAN VUUREN, S., VILJOEN, A., VAN ZYL, R.,VAN HEERDEN, F., BASER, K.H.C. (2006), The antimicrobial, antimalarial and toxicity profiles of helihumulone, leaf essential oil and extracts of Helichrysum cymosum (L.) D. Don subsp. cymosum, South African Journal of Botany; 72(2),287-290.

Determination of antimutagenic properties of Helichrysum plicatum DC. subsp. plicatum by Micronuclei and COMET Methods

Year 2019, Volume: 5 Issue: 2, 36 - 39, 15.12.2019

Selçuk Çeker

Abstract

Helichrysum plicatum DC. subsp. plicatum (Asteraceae) is a
medicinal plant and natural product. This plant is commonly found in Anatolia
and has been used in folk medicine for thousands of years. There are many
studies in the literature investigating the biological properties of this
plant, but few studies have investigated anti-mutagenic activities. In this
study, the antimutagenic of different concentrations of Helichrysum plicatum DC. subsp. plicatum methanol extract (5, 10,
25, 50, 100, 200 and 300 µgr / mL) was investigated using the micronuclei and
the single cell gel electrophoresis test systems. Aflatoxin B1 was
used as positive control and pure water was used as negative control. As a
result, Helichrysum plicatum DC. subsp.
plicatum was found to have antimutagenic activity in both test systems and
the most effective results were obtained from 100 ugr
/ mL concentration.

Keywords

Helichrysum plicatum aflatoxin B1

References

  • ALBAYRAK, S., AKSOY, A., SAGDIC, O., BUDAK, U. (2010), Phenolic compounds and antioxidant and antimicrobial properties of Helichrysum species collected from eastern Anatolia, Turkey, Turkish Journal of Biology; 34(4), 463-473.
  • ANDERSON, D., YU, T.W., PHILLIPS, B., SCHMEZER, P. (1994), The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; 307(1), 261-271.
  • ASLAN, M., ORHAN, D.D., ORHAN, N., SEZIK, E., YESILADA, E. (2007), In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. plicatum capitulums in streptozotocin-induced-diabetic rats, Journal of ethnopharmacology; 109(1), 54-59.
  • BAYIR, Y., HALICI, Z., KELES, M.S., COLAK, S., CAKIR, A., KAYA, Y., AKCAY, F. (2011), Helichrysum plicatum DC. subsp. plicatum extract as a preventive agent in experimentally induced urolithiasis model, Journal of ethnopharmacology; 138(2), 408-414.
  • BAYTOP, T. (1999), Türkiye'de bitkiler ile tedavi: geçmişte ve bugün, Nobel Tıp Kitabevleri.
  • BIGOVIĆ, D., ŠAVİKİN, K., JANKOVİĆ, T., MENKOVİĆ, N., ZDUNİĆ, G., STANOJKOVİĆ, T., DJURİĆ, Z. (2011), Antiradical and cytotoxic activity of different Helichrysum plicatum flower extracts, Natural product communications; 6(6), 1934578X1100600617.
  • COLLINS, A.R., AI-GUO M., DUTHIE, S.J. (1995), The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells, Mutation Research/DNA Repair; 336(1), 69-77.
  • DEMIREL, S., ZAMANI, A.G., (2002), Mikronükleus tekniği ve kullanım alanları, Genel Tıp Dergisi; 12(3),123-127.
  • EROGLU, H.E., AKSOY, A., HAMZAOGLU, E., BUDAK, U., ALBAYRAK, S. (2009), Cytogenetic effects of nine Helichrysum taxa in human lymphocytes culture, Cytotechnology; 59(1),65-72.
  • FENECH, M. (2000), The in vitro micronucleus technique, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; 455(1-2),81-95.
  • JENA, G., KAUL, C., RAMARAO, P. (2002), Genotoxicity testing, a regulatory requirement for drug discovery and development: impact of ICH guidelines, Indian journal of pharmacology; 34(2),86-99.
  • KOTAN, R., DADASOGLU, F., KORDALI, S., CAKIR, A., DIKBAS, N., CAKMAKCI, R. (2007), Antibacterial activity of essential oils extracted from some medicinal plants, carvacrol and thymol on Xanthomonas axonopodis pv. vesicatoria (Doidge) Dye causes bacterial spot disease on pepper and tomato, Journal of Agricultural Technology; 3(2), 299-306.
  • KULEVANOVA, S., STEFOVA, M., STAFILOV, T. (2000), HPLC identification and determination of flavone aglycones in Helichrysum plicatum DC.(Asteraceae), Die Pharmazie; 55(5),391.
  • KURTULMUS, S., AYDIN, A. (2007), Dental döküm alaşımlarının genotoksisite, mutajenisite ve karsinojenisitesi, Selçuk Üniversitesi Dişhekimliği Fakültesi Dergisi;16,73-78.
  • MEYER, J., AFOLAYAN, A., TAYLOR, M., ERASMUS, D. (1997), Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens, Journal of ethnopharmacology; 56(2),165-169.
  • ORHAN, F., CEKER, S., ANAR, M., AGAR, G., ARASOGLU, T., GULLUCE, M. (2016), Protective effects of three luteolin derivatives on aflatoxin B 1-induced genotoxicity on human blood cells, Medicinal chemistry research; 25(11), 2567-2577.
  • OZTURK, B., OZEK, G., OZEK, T., BASER, K.H.C. (2014), Chemical diversity in volatiles of Helichrysum plicatum DC. subspecies in Turkey, Records of Natural Products; 8(4), 373.
  • SCHINELLA, G., TOURNIER, H., PRIETO, J., DE BUSCHIAZZO, P.M., RIOS, J. (2002), Antioxidant activity of anti-inflammatory plant extracts, Life sciences;70(9),1023-1033.
  • SINGH, N.P., MCCOY, M.T., TICE, R.R., SCHNEIDER, E.L. (1988), A simple technique for quantitation of low levels of DNA damage in individual cells, Experimental cell research; 175(1),184-191.
  • TEPE, B., SOKMEN, M., AKPULAT, H.A., SOKMEN, A. (2005), In vitro antioxidant activities of the methanol extracts of four Helichrysum species from Turkey, Food Chemistry; 90(4), 685-689.
  • TICE, R.R., AGURELL, E., ANDERSON, D., BURLINSON, B., HARTMANN, A., KOBAYASHI, H., MIYAMAE, Y., ROJAS, E., RYU, J.C., SASAKI, Y. (2000), Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing, Environmental and molecular mutagenesis; 35(3), 206-221.
  • VAN VUUREN, S., VILJOEN, A., VAN ZYL, R.,VAN HEERDEN, F., BASER, K.H.C. (2006), The antimicrobial, antimalarial and toxicity profiles of helihumulone, leaf essential oil and extracts of Helichrysum cymosum (L.) D. Don subsp. cymosum, South African Journal of Botany; 72(2),287-290.
There are 22 citations in total.

Details

Primary Language English
Journal Section makaleler
Authors

Selçuk Çeker 0000-0002-2795-8863

Publication Date December 15, 2019
Published in Issue Year 2019 Volume: 5 Issue: 2

Cite

APA Çeker, S. (2019). Determination of antimutagenic properties of Helichrysum plicatum DC. subsp. plicatum by Micronuclei and COMET Methods. Eastern Anatolian Journal of Science, 5(2), 36-39.
AMA Çeker S. Determination of antimutagenic properties of Helichrysum plicatum DC. subsp. plicatum by Micronuclei and COMET Methods. Eastern Anatolian Journal of Science. December 2019;5(2):36-39.
Chicago Çeker, Selçuk. “Determination of Antimutagenic Properties of Helichrysum Plicatum DC. Subsp. Plicatum by Micronuclei and COMET Methods”. Eastern Anatolian Journal of Science 5, no. 2 (December 2019): 36-39.
EndNote Çeker S (December 1, 2019) Determination of antimutagenic properties of Helichrysum plicatum DC. subsp. plicatum by Micronuclei and COMET Methods. Eastern Anatolian Journal of Science 5 2 36–39.
IEEE S. Çeker, “Determination of antimutagenic properties of Helichrysum plicatum DC. subsp. plicatum by Micronuclei and COMET Methods”, Eastern Anatolian Journal of Science, vol. 5, no. 2, pp. 36–39, 2019.
ISNAD Çeker, Selçuk. “Determination of Antimutagenic Properties of Helichrysum Plicatum DC. Subsp. Plicatum by Micronuclei and COMET Methods”. Eastern Anatolian Journal of Science 5/2 (December 2019), 36-39.
JAMA Çeker S. Determination of antimutagenic properties of Helichrysum plicatum DC. subsp. plicatum by Micronuclei and COMET Methods. Eastern Anatolian Journal of Science. 2019;5:36–39.
MLA Çeker, Selçuk. “Determination of Antimutagenic Properties of Helichrysum Plicatum DC. Subsp. Plicatum by Micronuclei and COMET Methods”. Eastern Anatolian Journal of Science, vol. 5, no. 2, 2019, pp. 36-39.
Vancouver Çeker S. Determination of antimutagenic properties of Helichrysum plicatum DC. subsp. plicatum by Micronuclei and COMET Methods. Eastern Anatolian Journal of Science. 2019;5(2):36-9.