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Mide ve kolorektal kanserli hastalarda preoperatif nötrofil/lenfosit ve trombosit / lenfosit oranlarının klinik önemi

Yıl 2020, Cilt: 5 Sayı: 2, 43 - 47, 31.08.2020
https://doi.org/10.25000/acem.703750

Öz

Amaç: Gastrik kanser (GK) ve kolorektal kanser (KRK) gibi gastrointestinal ilişkili kanserler, önemli bir halk sağlığı problemi haline gelmiştir ve preoperatif değerlendirme, ilk tedavi stratejilerinin belirlenmesinde oldukça önemlidir. Bu çalışma, GK ve KRK hastalarında preoperatif nötrofil-lenfosit oranı (NLO) ve trombosit-lenfosit oranı (TLO)'nın olası prognostik değerini değerlendirmek için yapıldı. Yöntemler: Bu retrospektif çalışmaya 50 GK, 50 ardışık KRK hastasını ve yaşları eşleştirilmiş 60 ardışık sağlıklı kişi (kontrol grubu) alındı. Preoperatif tam kan sayımı sonuçları (nötrofiller, trombositler ve lenfositler) hastanın tıbbi kayıtlarından alındı. Bulgular: NLO ve TLO değerleri hem GK hem de KRK hastalarında kontrol grubuna göre anlamlı olarak yüksek bulundu (her ikisi de p <0.001). KRK hastalarında TLO değerleri GK hastalarına göre anlamlı derecede yüksek bulundu (p <0.01). NLO ve TLO değerleri hem GK hem de KRK hastalarında kontrol grubuna göre anlamlı olarak yüksek bulundu (her ikisi de p <0.001). NLO ve TLO değerleri hem gastrik hem de kolorektal kanserin evre 4 hastalarında evre 3 hastalara göre anlamlı derecede yüksek bulundu (her ikisi de p <0.001). Hem GK hem de KRK hastalarında NLO, lenfosit sayısıyla negatif olarak ilişkiliyken, nötrofil sayısı, trombosit ve TLO ile pozitif olarak ilişkiliydi. Sonuç: GC ve CRC'de, NLO ve TLO, önemli bir öngörücü biyobelirteç olabilir. NLO ve TLO değerlerinin, GK ve KRK hastalarında klinik önemi tahmin etmek için basit, uygulanabilir, ucuz ve kullanışlı parametreler olarak kullanılabileceği sonucuna varıldı. Sonuçlar klinik uygulamada daha geniş çaplı çalışmalarda doğrulanmalıdır.

Kaynakça

  • 1. Sisik A, Kaya M, Bas G, Basak F, Alimoglu O. CEA and CA 19-9 are still valuable markers for the prognosis of colorectal and gastric cancer patients. Asian Pac J Cancer Prev. 2013;14:4289-94.
  • 2. Fu JJ, Baines KJ, Wood LG, et al. Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma. OMICS 2013;17:187–99.
  • 3. Kemp MW, Kannan PS, Saito M, et al. Selective exposure of the fetal lung and skin/amnion (but not gastro-intestinal tract) to LPS elicits acute systemic inflammation in fetal sheep. PloS One 2013;8:e63355.
  • 4. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420: 860–7.
  • 5. Teramukai S, Kitano T, Kishida Y, Kavvahara M, Kubota K, Komuta K, Minato K, Mio T Fujita Y, Yonei T, Nakano K, Tsuboi M, Shibata K, Furuse K, Fukushima M. Pretreatment neutrophil count as an independent prognostic factor in advanced non small celi lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03. Eur J Cancer 2009; 45:1950-8.
  • 6. Yamanaka T, Matsumoto S, Teramukai S, Ishivvata R, Nagai Y, Fukushima M. The baseline ratio of neutrophils to lymphocytes vvith patient prognosis in advanced gastric cancer. Oncology 2007; 73:215-20.
  • 7. Smith RA, Ghaneh P, Sutton R, Raraty M, Campbell F, Neoptolemos JP. Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio. J Gastrointest Surg 2008; 12:1422-8.
  • 8. Shimada H, Oohira G, Okazumi S, Matsubara H, Nabeya Y, Hayashi H, Takeda A, Gunji Y, Ochiai T. Thrombocytosis associated vvith poor prognosis in patients vvith esophageai carcinoma. J Am Coll Surg 2004; 198:737-41.
  • 9. Rodriguez GC, Clarke-Pearson DL, Soper JT, Berchuck A, Synan I, Dodge RK. The negative prognostic implications of thrombocytosis in women vvith stage IB cervicai cancer. Obstet Gynecl 1994; 83:445-8.
  • 10. Ropponen KM, Eskelinen MJ, Lipponen PK, et al. Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol 1997;182:318–24.
  • 11. Donskov F. Immunomonitoring and prognostic relevance of neutrophils in clinical trials. Semin Cancer Biol 2013;23:200–7.
  • 12. Templeton AJ, Ace O, McNamara MG, et al. Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and metaanalysis. Cancer Epidemiol Biomarkers Prev 2014;23:1204–12.
  • 13. Aliustaoğlu M, Ustaalioğlu ÖBB, Bilici A, Konya V, Gücün M, Şeker M, Gümüş M. Is the complete blood count parameters predict prognosis before treatment in metastatic gastric cancer patients? Acta Oncoligica Turcica 2010; 43; 13-18.
  • 14. Hong WS, Hong SI, Kim CM, Kang YK, Song JK, Lee MS, Lee JO, Kang TW. Differential depression of lymphocyte subsets according to stage in stomach cancer. Jpn J Clin Oncol 1991; 21:87-93.
  • 15. Hong WS, Min Yİ, Son YS, Hong SI. Peripheral blood lymphocyte subsets in patients with stomach cancer. J Korean Med Sci 1995; 10:164-8.
  • 16. Ikeda M, Furukavva H, Imamura H, Shimizu J, Ishida H, Masu- tani S, Tatsuta M, Satomi T. Poor prognosis associated with thrombocytosis in patients with gastric cancer. Ann Surg Oncol 2002; 9:287-91.
  • 17. Gwak MS, Choi SJ, Kim JA, Ko JS, Kim TH, Lee SM, Park JA, Kim MH. Effects of gender on white blood cell populations and neutrophil-lymphocyte ratio following gastrectomy in patients with stomach cancer. J Korean Med Sci 2007; 22:104-8.
  • 18. Szor DJ, Dias AR, Pereira MA, Ramos MFKP, Zilberstein B, Cecconello I, Ribeiro-Júnior U. Prognostic Role of Neutrophil/Lymphocyte Ratio in Resected Gastric Cancer: A Systematic Review and Meta-analysis. Clinics (Sao Paulo). 2018;73:e360.
  • 19. Lian L, Xia YY, Zhou C, Shen XM, Li XL, Han SG, Zheng Y, Mao ZQ, Gong FR, Wu MY, Chen K, Tao M, Li W. Application of platelet/lymphocyte and neutrophil / lymphocyte ratios in early diagnosis and prognostic prediction in patients with resectable gastric cancer. Cancer Biomark. 2015;15(6):899-907.
  • 20. Xin-Ji Z, Yong-Gang L, Xiao-Jun S, Xiao-Wu C, Dong Z, Da-Jian Z. The prognostic role of neutrophils to lymphocytes ratio and platelet count in gastric cancer: A meta-analysis. Int J Surg. 2015;21:84–91.
  • 21. Sun J, Chen X, Gao P, Song Y, Huang X, Yang Y, et al. Can the Neutrophil to Lymphocyte Ratio Be Used to Determine Gastric Cancer Treatment Outcomes? A Systematic Review and Meta-Analysis. Dis Markers. 2016;2016:7862469.
  • 22. Hsu JT, Liao CK, Le PH, Chen TH, Lin CJ, Chen JS, et al. Prognostic Value of the Preoperative Neutrophil to Lymphocyte Ratio in Resectable Gastric Cancer. Medicine (Baltimore) 2015;94:e1589.
  • 23. Mellor KL, Powell AGMT, Lewis WG. Systematic Review and Meta-Analysis of the Prognostic Significance of Neutrophil-Lymphocyte Ratio (NLR) After R0 Gastrectomy for Cancer. J Gastrointest Cancer. 2018; 49: 237-244.
  • 24. Zhou WW, Chu YP, An GY. Significant difference of neutrophil-lymphocyte ratio between colorectal cancer, adenomatous polyp and healthy people. Eur Rev Med Pharmacol Sci. 2017; 21: 5386-5391.
  • 25. Palin RP, Devine AT, Hicks G, Burke D. Association of pretreatment neutrophil-lymphocyte ratio and outcome in emergency colorectal cancer care. Ann R Coll Surg Engl. 2018; 100: 308-315.
  • 26. Silva TH, Schilithz AOC, Peres WAF, Murad LB. Neutrophil-lymphocyte ratio and nutritional status are clinically useful in predicting prognosis in colorectal cancer patients. Nutr Cancer. 2019: 1-10.
  • 27. Eto S, Kawahara H, Matsumoto T, Hirabayashi T, Omura N, Yanaga K. Preoperative Neutrophil-Lymphocyte Ratio Is a Predictor of Bowel Obstruction Due to Colorectal Cancer Growth. Anticancer Res. 2019; 39: 3185-9.
  • 28. Templeton AJ, Ace O, McNamara MG, Al-Mubarak M, Vera-Badillo FE, Hermanns T, Seruga B, Ocaña A, Tannock IF, Amir E. Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and metaanalysis. Cancer Epidemiol Biomark Prev. 2014;23:1204–12.
  • 29. Lu C, Gao P, Yang Y, Chen X, Wang L, Yu D, Song Y, Xu Q, Wang Z. Prognostic evaluation of platelet to lymphocyte ratio in patients with colorectal cancer. Oncotarget. 2017;8:86287–95.
  • 30. He W, Yin C, Guo G, Jiang C, Wang F, Qiu H, Chen X, Rong R, Zhang B, Xia L. Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer. Med Oncol. 2013; 30: 439.
  • 31. Choi WJ, Cleghorn MC, Jiang H, Jackson TD, Okrainec A, Quereshy FA. Preoperative neutrophil-to-lymphocyte ratio is a better prognostic serum biomarker than platelet-to-lymphocyte ratio in patients undergoing resection for nonmetastatic colorectal cancer. Ann Surg Oncol. 2015; 22 Suppl 3:S603-13.
  • 32. Li ZM, Peng YF, Du CZ, Gu J. Colon cancer with unresectable synchronous metastases: the AAAP scoring system for predicting the outcome after primary tumour resection. Colorectal Dis. 2016; 18: 255-63.
  • 33. Son HJ, Park JW, Chang HJ, Kim DY, Kim BC, Kim SY, Park SC, Choi HS, Oh JH. Preoperative plasma hyperfibrinogenemia is predictive of poor prognosis in patients with nonmetastatic colon cancer. Ann Surg Oncol. 2013; 20: 2908-13.
  • 34. Ying HQ, Deng QW, He BS, Pan YQ, Wang F, Sun HL, Chen J, Liu X, Wang SK. The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients. Med Oncol. 2014; 31: 305.
  • 35. Azab B, Mohammad F, Shah N, Vonfrolio S, Lu W, Kedia S, Bloom SW The value of the pretreatment neutrophil lymphocyte ratio vs. platelet lymphocyte ratio in predicting the long-term survival in colorectal cancer. Cancer Biomark. 2014; 14: 303-12.
  • 36. Choi WJ, Cleghorn MC, Jiang H, Jackson TD, Okrainec A, Quereshy FA. Preoperative Neutrophil-to-Lymphocyte Ratio is a Better Prognostic Serum Biomarker than Platelet-to-Lymphocyte Ratio in Patients Undergoing Resection for Nonmetastatic Colorectal Cancer. Ann Surg Oncol. 2015; 22 Suppl 3: S603-13.
  • 37. Ying HQ, Deng QW, He BS, Pan YQ, Wang F, Sun HL, Chen J, Liu X, Wang SK. The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients. Med Oncol. 2014; 31: 305.
  • 38. Huang XZ, Chen WJ, Zhang X, Wu CC, Zhang CY, Sun SS, Wu J. An Elevated Platelet-to-Lymphocyte Ratio Predicts Poor Prognosis and Clinicopathological Characteristics in Patients with Colorectal Cancer: A Meta-Analysis. Dis Markers. 2017; 2017: 1053125.

The clinical significance of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in patients with gastric or colorectal cancer

Yıl 2020, Cilt: 5 Sayı: 2, 43 - 47, 31.08.2020
https://doi.org/10.25000/acem.703750

Öz

Giriş ve Amaç: Gastrik kanser (GK) ve kolorektal kanser (KRK) gibi gastrointestinal ilişkili kanserler, önemli bir halk sağlığı problemi haline gelmiştir ve preoperatif değerlendirme, ilk tedavi stratejilerinin belirlenmesinde oldukça önemlidir. Bu çalışma, GK ve KRK hastalarında preoperatif nötrofil-lenfosit oranı (NLO) ve trombosit-lenfosit oranı (TLO)'nın olası prognostik değerini değerlendirmek için yapıldı. Gereç ve Yöntem: Bu retrospektif çalışmaya 50 GK, 50 ardışık KRK hastasını ve yaşları eşleştirilmiş 60 ardışık sağlıklı kişi (kontrol grubu) alındı. Preoperatif tam kan sayımı sonuçları (nötrofiller, trombositler ve lenfositler) hastanın tıbbi kayıtlarından alındı. Bulgular: NLO ve TLO değerleri hem GK hem de KRK hastalarında kontrol grubuna göre anlamlı olarak yüksek bulundu (her ikisi de p <0.001). KRK hastalarında TLO değerleri GK hastalarına göre anlamlı derecede yüksek bulundu (p <0.01). NLO ve TLO değerleri hem GK hem de KRK hastalarında kontrol grubuna göre anlamlı olarak yüksek bulundu (her ikisi de p <0.001). NLO ve TLO değerleri hem gastrik hem de kolorektal kanserin evre 4 hastalarında evre 3 hastalara göre anlamlı derecede yüksek bulundu (her ikisi de p <0.001). Hem GK hem de KRK hastalarında NLO, lenfosit sayısıyla negatif olarak ilişkiliyken, nötrofil sayısı, trombosit ve TLO ile pozitif olarak ilişkiliydi. Sonuç: GC ve CRC'de, NLO ve TLO, önemli bir öngörücü biyobelirteç olabilir. NLO ve TLO değerlerinin, GK ve KRK hastalarında prognozu tahmin etmek için basit, uygulanabilir, ucuz ve kullanışlı parametreler olarak kullanılabileceği sonucuna varıldı. Sonuçlar klinik uygulamada daha geniş çaplı çalışmalarda doğrulanmalıdır.

Kaynakça

  • 1. Sisik A, Kaya M, Bas G, Basak F, Alimoglu O. CEA and CA 19-9 are still valuable markers for the prognosis of colorectal and gastric cancer patients. Asian Pac J Cancer Prev. 2013;14:4289-94.
  • 2. Fu JJ, Baines KJ, Wood LG, et al. Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma. OMICS 2013;17:187–99.
  • 3. Kemp MW, Kannan PS, Saito M, et al. Selective exposure of the fetal lung and skin/amnion (but not gastro-intestinal tract) to LPS elicits acute systemic inflammation in fetal sheep. PloS One 2013;8:e63355.
  • 4. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420: 860–7.
  • 5. Teramukai S, Kitano T, Kishida Y, Kavvahara M, Kubota K, Komuta K, Minato K, Mio T Fujita Y, Yonei T, Nakano K, Tsuboi M, Shibata K, Furuse K, Fukushima M. Pretreatment neutrophil count as an independent prognostic factor in advanced non small celi lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03. Eur J Cancer 2009; 45:1950-8.
  • 6. Yamanaka T, Matsumoto S, Teramukai S, Ishivvata R, Nagai Y, Fukushima M. The baseline ratio of neutrophils to lymphocytes vvith patient prognosis in advanced gastric cancer. Oncology 2007; 73:215-20.
  • 7. Smith RA, Ghaneh P, Sutton R, Raraty M, Campbell F, Neoptolemos JP. Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio. J Gastrointest Surg 2008; 12:1422-8.
  • 8. Shimada H, Oohira G, Okazumi S, Matsubara H, Nabeya Y, Hayashi H, Takeda A, Gunji Y, Ochiai T. Thrombocytosis associated vvith poor prognosis in patients vvith esophageai carcinoma. J Am Coll Surg 2004; 198:737-41.
  • 9. Rodriguez GC, Clarke-Pearson DL, Soper JT, Berchuck A, Synan I, Dodge RK. The negative prognostic implications of thrombocytosis in women vvith stage IB cervicai cancer. Obstet Gynecl 1994; 83:445-8.
  • 10. Ropponen KM, Eskelinen MJ, Lipponen PK, et al. Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol 1997;182:318–24.
  • 11. Donskov F. Immunomonitoring and prognostic relevance of neutrophils in clinical trials. Semin Cancer Biol 2013;23:200–7.
  • 12. Templeton AJ, Ace O, McNamara MG, et al. Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and metaanalysis. Cancer Epidemiol Biomarkers Prev 2014;23:1204–12.
  • 13. Aliustaoğlu M, Ustaalioğlu ÖBB, Bilici A, Konya V, Gücün M, Şeker M, Gümüş M. Is the complete blood count parameters predict prognosis before treatment in metastatic gastric cancer patients? Acta Oncoligica Turcica 2010; 43; 13-18.
  • 14. Hong WS, Hong SI, Kim CM, Kang YK, Song JK, Lee MS, Lee JO, Kang TW. Differential depression of lymphocyte subsets according to stage in stomach cancer. Jpn J Clin Oncol 1991; 21:87-93.
  • 15. Hong WS, Min Yİ, Son YS, Hong SI. Peripheral blood lymphocyte subsets in patients with stomach cancer. J Korean Med Sci 1995; 10:164-8.
  • 16. Ikeda M, Furukavva H, Imamura H, Shimizu J, Ishida H, Masu- tani S, Tatsuta M, Satomi T. Poor prognosis associated with thrombocytosis in patients with gastric cancer. Ann Surg Oncol 2002; 9:287-91.
  • 17. Gwak MS, Choi SJ, Kim JA, Ko JS, Kim TH, Lee SM, Park JA, Kim MH. Effects of gender on white blood cell populations and neutrophil-lymphocyte ratio following gastrectomy in patients with stomach cancer. J Korean Med Sci 2007; 22:104-8.
  • 18. Szor DJ, Dias AR, Pereira MA, Ramos MFKP, Zilberstein B, Cecconello I, Ribeiro-Júnior U. Prognostic Role of Neutrophil/Lymphocyte Ratio in Resected Gastric Cancer: A Systematic Review and Meta-analysis. Clinics (Sao Paulo). 2018;73:e360.
  • 19. Lian L, Xia YY, Zhou C, Shen XM, Li XL, Han SG, Zheng Y, Mao ZQ, Gong FR, Wu MY, Chen K, Tao M, Li W. Application of platelet/lymphocyte and neutrophil / lymphocyte ratios in early diagnosis and prognostic prediction in patients with resectable gastric cancer. Cancer Biomark. 2015;15(6):899-907.
  • 20. Xin-Ji Z, Yong-Gang L, Xiao-Jun S, Xiao-Wu C, Dong Z, Da-Jian Z. The prognostic role of neutrophils to lymphocytes ratio and platelet count in gastric cancer: A meta-analysis. Int J Surg. 2015;21:84–91.
  • 21. Sun J, Chen X, Gao P, Song Y, Huang X, Yang Y, et al. Can the Neutrophil to Lymphocyte Ratio Be Used to Determine Gastric Cancer Treatment Outcomes? A Systematic Review and Meta-Analysis. Dis Markers. 2016;2016:7862469.
  • 22. Hsu JT, Liao CK, Le PH, Chen TH, Lin CJ, Chen JS, et al. Prognostic Value of the Preoperative Neutrophil to Lymphocyte Ratio in Resectable Gastric Cancer. Medicine (Baltimore) 2015;94:e1589.
  • 23. Mellor KL, Powell AGMT, Lewis WG. Systematic Review and Meta-Analysis of the Prognostic Significance of Neutrophil-Lymphocyte Ratio (NLR) After R0 Gastrectomy for Cancer. J Gastrointest Cancer. 2018; 49: 237-244.
  • 24. Zhou WW, Chu YP, An GY. Significant difference of neutrophil-lymphocyte ratio between colorectal cancer, adenomatous polyp and healthy people. Eur Rev Med Pharmacol Sci. 2017; 21: 5386-5391.
  • 25. Palin RP, Devine AT, Hicks G, Burke D. Association of pretreatment neutrophil-lymphocyte ratio and outcome in emergency colorectal cancer care. Ann R Coll Surg Engl. 2018; 100: 308-315.
  • 26. Silva TH, Schilithz AOC, Peres WAF, Murad LB. Neutrophil-lymphocyte ratio and nutritional status are clinically useful in predicting prognosis in colorectal cancer patients. Nutr Cancer. 2019: 1-10.
  • 27. Eto S, Kawahara H, Matsumoto T, Hirabayashi T, Omura N, Yanaga K. Preoperative Neutrophil-Lymphocyte Ratio Is a Predictor of Bowel Obstruction Due to Colorectal Cancer Growth. Anticancer Res. 2019; 39: 3185-9.
  • 28. Templeton AJ, Ace O, McNamara MG, Al-Mubarak M, Vera-Badillo FE, Hermanns T, Seruga B, Ocaña A, Tannock IF, Amir E. Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and metaanalysis. Cancer Epidemiol Biomark Prev. 2014;23:1204–12.
  • 29. Lu C, Gao P, Yang Y, Chen X, Wang L, Yu D, Song Y, Xu Q, Wang Z. Prognostic evaluation of platelet to lymphocyte ratio in patients with colorectal cancer. Oncotarget. 2017;8:86287–95.
  • 30. He W, Yin C, Guo G, Jiang C, Wang F, Qiu H, Chen X, Rong R, Zhang B, Xia L. Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer. Med Oncol. 2013; 30: 439.
  • 31. Choi WJ, Cleghorn MC, Jiang H, Jackson TD, Okrainec A, Quereshy FA. Preoperative neutrophil-to-lymphocyte ratio is a better prognostic serum biomarker than platelet-to-lymphocyte ratio in patients undergoing resection for nonmetastatic colorectal cancer. Ann Surg Oncol. 2015; 22 Suppl 3:S603-13.
  • 32. Li ZM, Peng YF, Du CZ, Gu J. Colon cancer with unresectable synchronous metastases: the AAAP scoring system for predicting the outcome after primary tumour resection. Colorectal Dis. 2016; 18: 255-63.
  • 33. Son HJ, Park JW, Chang HJ, Kim DY, Kim BC, Kim SY, Park SC, Choi HS, Oh JH. Preoperative plasma hyperfibrinogenemia is predictive of poor prognosis in patients with nonmetastatic colon cancer. Ann Surg Oncol. 2013; 20: 2908-13.
  • 34. Ying HQ, Deng QW, He BS, Pan YQ, Wang F, Sun HL, Chen J, Liu X, Wang SK. The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients. Med Oncol. 2014; 31: 305.
  • 35. Azab B, Mohammad F, Shah N, Vonfrolio S, Lu W, Kedia S, Bloom SW The value of the pretreatment neutrophil lymphocyte ratio vs. platelet lymphocyte ratio in predicting the long-term survival in colorectal cancer. Cancer Biomark. 2014; 14: 303-12.
  • 36. Choi WJ, Cleghorn MC, Jiang H, Jackson TD, Okrainec A, Quereshy FA. Preoperative Neutrophil-to-Lymphocyte Ratio is a Better Prognostic Serum Biomarker than Platelet-to-Lymphocyte Ratio in Patients Undergoing Resection for Nonmetastatic Colorectal Cancer. Ann Surg Oncol. 2015; 22 Suppl 3: S603-13.
  • 37. Ying HQ, Deng QW, He BS, Pan YQ, Wang F, Sun HL, Chen J, Liu X, Wang SK. The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients. Med Oncol. 2014; 31: 305.
  • 38. Huang XZ, Chen WJ, Zhang X, Wu CC, Zhang CY, Sun SS, Wu J. An Elevated Platelet-to-Lymphocyte Ratio Predicts Poor Prognosis and Clinicopathological Characteristics in Patients with Colorectal Cancer: A Meta-Analysis. Dis Markers. 2017; 2017: 1053125.
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi
Bölüm Orjinal Makale
Yazarlar

Berrin Papila Kundaktepe 0000-0003-4394-3976

Yayımlanma Tarihi 31 Ağustos 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 5 Sayı: 2

Kaynak Göster

Vancouver Papila Kundaktepe B. The clinical significance of preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in patients with gastric or colorectal cancer. Arch Clin Exp Med. 2020;5(2):43-7.