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Cognitive Dysfunction in Fibromyalgia

Yıl 2015, Cilt: 24 Sayı: 1, 105 - 118, 17.11.2014
https://doi.org/10.17827/aktd.07534

Öz

The primary symptom of fibromyalgia is widespread pain with muscle tenderness to light palpation. Howeover many patients report a wide range of symptoms including pain, dyscognition, sleep disturbances, fatigue and mood disorders (frequently depression). Such symptoms seem to be related to one another. Besides, a decrease in concentration and memory disorder has recognised as an independent symptom yet; added into literature under the terms ‘dyscognition’ and ‘fibrofog’. Recently clinicians interested in investigations about dyscognition in fibromyalgia syndrome. Cognitive symptoms may be exacerbated by the presence of depression, anxiety, sleep dysorders, endocrine disregulations and pain; but the relationship is unclear. Additionally some of recent studies suggest that insulin resistance may represent a risk factor for memory impairment in these patients. There is lack of standardized tests, treatment methods and studies for understanding pathophysiologic pathways of cognitive problems (memory, concentration) in fibromyalgia.

Kaynakça

  • Bennet RM, Jones J, Turk DC, Russell IJ, Matallana L. An internet survey of 2.596 people with fibromyalgia. BMC Musculoskelet Disord. 2007;8:27.
  • Wolfe F, Ross K, Anderson J, Russel IJ, Hebert L. The prevelance and characteristics of fibromyalgia in the general population. Arthritis Rheum. 1995;38:19-28.
  • Clauw DJ. Fibromyalgia: an overwiev. Am J Med. 2009;122:3-13.
  • Symthe HA, Moldofsky H. Two contributions to understanding of the 'fibrositis' syndrome: clinical study of 50 patients with matched normal controls. Bull Rheum Dis. 1977;28:928-31.
  • Podolecki T, Podolecki A, Hrycek A. Fibromyalgia: pathogenetic, diagnostic and therapeutic concerns. Pol Arch Med Wewn. 2009;119:157-61.
  • Stahl SM. Fibromyalgia-pathways and neurotransmitters. Hum Psychopharmacol. 2009;24:11-7.
  • .Jin H, Patil PM, Sharma A. Topical review: the enigma of fibromyalgia. J Oral Facial Pain Headache. 2014;28:107-18.
  • Mease P. Fibromyalgia syndrome: review of clinical presentation, pathogenesis, outcome measures, and treatment. J Rheumatol Suppl. 2005;75:6-21.
  • Fayed N, Andres E, Rojas G, Moreno S, Serrano-Blanco A, Roca M et al. Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study. Acta Psychiatr Scand. 2012;126:115-25.
  • Wolfe F, Symthe HA, Yunus MB, Bennet RM, Bombardier C, Goldenberg DL et al. The American College of Rheumatology 1990 criteria for the classification of the fibromyalgia: report of the multicenter criteria committee. Arthritis Rheum. 1990;33:160-72.
  • Bennett R, Friend R, Marcus D, Bernstein C, Han BK, Yachoui R et al. Criteria for the diagnosis of fibromyaljia: Validation of the modified 2010 preliminary ACR criteria and the development of alternative criteria. Arthritis Care Res (Hoboken). 2014;66:1364-73.
  • Fitzcharles MA, Shir Y, Ablin JN, Buskila D, Amital H, Henningsen P et al. Classification and clinical diagnosis of fibromyalgia syndrome: recommendations of recent evidence-based interdisciplinary guidelines. Evid Based Complement Alternat Med. 2013;2013:528952.
  • Belenguer R, Siso A, Ramos-Casals M. Fibromyalgia classification: are there different classes of patients? Rev Fac Cien Med Unıv Nac Cordoba. 2009;66:146-57.
  • Sarzi-Puttini P, Atzeni F, Di Franco M, Buskila D, Alciati A, Giacomelli C et al. Dysfunctional syndromes and fibromyalgia: a 2012 critical digest. Clin Exp Rheumatol. 2012;30:143-51.
  • Munguia-Izquerdo D, Legaz-Arrese A, Moliner-Urdiales D, Reverter-Masia J. Neuropsychological performance in patients with fibromyalgia syndrome: relation to pain and anxiety. Psicothema. 2008;20:427-3.
  • Schmidt-Wilcke T, Wood P, Lürding R. Cognitive impairment in patients suffering from fibromyalgia. An underestimated problem.Schmerz. 2010;24:46-53.
  • Periot-Nierga I, Hernandez-Ferrandiz M, Lozano-Gallego M, Vilalta-Franch J, Cruz-Reina Mdel M, Lopez-Pousa S. Cognitive profile in fibromyalgia. Comparison with a mild cognitive impairment group. Med Clin (Barc). 2009;133:91-4.
  • Dick BD, Verrier MJ, Harker KT, Rashiq S. Disruption of cognitive function in fibromyalgia syndrome. Pain. 2008;139:610-6.
  • Glass JM. Fibromyalgia and cognition.J Clin Psychiatry. 2008;69:20-4.
  • Katz RS, Heard AR, Millis M, Leavitt F. The prevalence and clinical impact of reported cognitive difficulties(fibrofog) in patients with rheumatic disease with and without fibromyalgia. J Clin Rheumatol. 2004;10:53-8.
  • Leavitt F, Katz RS, Mills M, Heard AR. Cognitive and dissociative manifestations in fibromyalgia. J Clin Rheumatol. 2002;8:77-84.
  • Tesio V, Torta DM, Colonna F, Leombruni P, Ghiggia A, Fusaro E et al. Are fibromyalgia patients cognitively impaired? Objective and subjective neuropsychological evidence.Artritis Care Res (Hoboken). 2014; doi: 10.1002/acr.22403.
  • Bertolucci PH, de Oliveira FF. Cognitive impairment in fibromyalgia. Curr Pain Headache Rep. 2013;17:344.
  • Folstein MF, Folstein SE, McHugh PR. ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. J Psyschiatr Res. 1975;12:189-98.
  • Rodrigez-Andreu J, Ibanez-Bosch R, Portero-Vazquez A, Masramon X, Rejas J, Galvez R. Cognitive impairment in patients with fibromyalgia syndrome as assessed by the mini-mental state examination. BMC Musculoskelet Disord. 2009;10:162.
  • Seo J, Kim SH, Kim YT, Song HJ, Lee JJ, Kim SH et al. Working memory impairment in fibromyalgia patients associated with altered frontoparietal memory network. PLoS One. 2012;7:e37808.
  • Kim SH, Kim SH, Kim SK, Nam EJ, Han SW, Lee SJ. Spatial versus verbal memory impairments in patients with fibromyalgia. Rheumatol Int. 2012;32:1135-42.
  • Gelonch O, Garolera M, Rossello L, Pifarre J. Cognitive dysfunction in fibromyalgia. Rev Neurol. 2013;56:573-88.
  • Duschek S, Werner NS, Winkelmann A, Wankner S. Implicit memory function in fibromyalgia syndrome. Behav Med. 2013;39:11-6.
  • Glass JM, Park DC. Cognitive dysfunction in fibromyalgia. Curr Rheumatol Rep. 2001;3:123-7.
  • WeiB S, Winkelmann A, Duschek S. Recognition of facially expressed emotions in patients with fibromyalgia syndrome. Behav Med. 2013;39:146-54.
  • Frange C, Hirotsu C, Hachul H, Araujo P, Tufik S, Andersen ML. Fibromyalgia and sleep in animal models: a current overview and future directions. Curr Pain Headache Rep. 2014;18:434.
  • Kleinman L, Mannix S, Arnold LM, Burbridge C, Howard K, McQuarrie K et al. Assesment of sleep in patients with fibromyalgia: qualitative development of the fibromyalgia sleep diary. Health Qual Life Outcomes. 2014;12:111.
  • Apairicio VA, Ortega FB, Carbonell-Baeza A, Camiletti D, Ruiz JR, Delgado-Fernandez M. Relationship of weight status with mental and physical health in female fibromyalgia patients. Obes Facts. 2011;4:443-8.
  • Arranz L, Canela MA, Rafecas M. Relationship between body mass index, fat mass and lean mass with SF-36 quality of life scores in a group of fibromyalgia patients. Rheumatol Int. 2012;32:3605-11.
  • Ursini F, Naty S, Grembiale RD. Fibromyalgia and obesity: the hidden link. Rheumatol Int. 2011;31:1403-8.
  • Arreghini M, Manzoni GM, Catelnuvo G, Santovito C, Capodaglio P. Impact of fibromyalgia on functioning in obese patients undergoing comprehensive rehabilitation. PLoS One. 2014;9:e91392.
  • Fava A, Plastino M, Cristiano D, Spano A, Cristofaro S, Opipari C et al. Insulin resistance possible risk factor for cognitive impairment in fibromialgic patients. Metab Brain Dis. 2013;28:619-27.
  • Braz Ade S, de Paula AP, Diniz Mde F, de Almeida RN. Non-pharmacological therapy and complementary and alternative medicine in fibromyalgia. Rev Bras Reumatol. 2011;51:269-82.
  • Henriksen M, Lund H, Christensen R, Jespersen A, Dreyer L, Bennet LM et al. Relationships between the fibromyalgia impact questionnaire, tender point count, and muscle strength in female patients with fibromyalgia: a cohort study. Arthritis Rheum. 2009;61:732-9.
  • Staud R, Robinson ME, Price DD. Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls. Pain. 2005;118:176-84.
  • Gonzalez Gonzalez J, Del Teso Rubio MD, Walino Paniagua CN, Criado-Alvarez JJ, Sanchez Holgado J. Symptomatic pain and fibromyalgia treatment through multidisciplinary approach for Primary Care. Reumatol Clin. 2014;pii:S1699-258X(14):00081-3.
  • Etnier JL, Karper WB, Gapin JI, Barella LA, Chang YK, Murphy KJ. Exercise, fibromyaljia, and fibrofog: a pilot study. J Phys Act Health. 2009;6:239-46.
  • Arnold LM. Strategies for managing fibromyalgia. Am J Med. 2009;122:31-43.
  • Lange M, Krohn-Grimberghe B, Petermann F. Effects of a cognitive-behavioral patient education on fibromyalgia: a controlled efficacy study. Z Rheumatol. 2011;70:324-31.
  • Jacopson SA, Simpson RG, Lubahn C, Hu C, Belden CM, Davis KJ et al. Characterization of fibromyalgia symptoms in patients 55-95 years old: a longitudinal study showing symptom persistence with suboptimal treatment. Aging Clin Exp Res. 2014; doi: 10.1007/s405520-014- 0238-7.
  • Cadenas-Sanchez C, Ruiz-Ruiz J. Effect of a physical activity program in patients with fibromyalgia: A systematic review. Med Clin (Barc). 2014. doi: 10.1016/j.medcli.2013.12.010.
  • Sauer K, Kemper C, Glaeske G. Fibromyalgia syndrome: prevalence, pharmacological and non- pharmacological interventions in outpatient health care. An analysis of statutory health insurance data.Joint Bone Spine. 2011;78:80-4.

Fibromiyaljide Kognitif Disfonksiyon

Yıl 2015, Cilt: 24 Sayı: 1, 105 - 118, 17.11.2014
https://doi.org/10.17827/aktd.07534

Öz

Fibromiyalji’de asıl semptom hafif palpasyon ile olan kas hassasiyeti ve yaygın ağrıdır. Bununla birlikte hastalar ağrı, kognitif disfonksiyon, uyku bozukluğu, yorgunluk ve duygudurum bozuklukları (sıklıkla depresyon) gibi geniş bir yelpazedeki semptomlardan yakınırlar. Bu semptomlar birbirleri ile ilişkili gibi görünmektedir. Bunların yanında konsantrasyonda azalma ve hafıza bozukluğu artık bağımsız bir semptom olarak ele alınmakla birlikte literatüre ‘kognitif disfonksiyon’ ve ‘fibro-fog’ terimleri adı altında eklenmiştir. Son yıllarda klinisyenler fibromiyalji sendromundaki kognitif disfonksiyon hakkındaki araştırmalara ilgi duymaya başlamışlardır. Kognitif semptomlar depresyon, anksiyete, uyku bozuklukları, endokrin dengesizlikler ve ağrı varlığında artış göstermektedir. Ek olarak yeni bazı çalışmalarda insülin direncinin bu hastalarda hafıza bozukluğu için risk faktörü olabileceğini desteklemektedir. Fibromiyalji’de ortaya çıkan kognitif problemlerde (hafıza, konsantrasyon) rol alan patofizyolojik yolakları açıklayacak ilgili çalışmalar, standardize tedavi metodları ve testler yetersizdir.

Kaynakça

  • Bennet RM, Jones J, Turk DC, Russell IJ, Matallana L. An internet survey of 2.596 people with fibromyalgia. BMC Musculoskelet Disord. 2007;8:27.
  • Wolfe F, Ross K, Anderson J, Russel IJ, Hebert L. The prevelance and characteristics of fibromyalgia in the general population. Arthritis Rheum. 1995;38:19-28.
  • Clauw DJ. Fibromyalgia: an overwiev. Am J Med. 2009;122:3-13.
  • Symthe HA, Moldofsky H. Two contributions to understanding of the 'fibrositis' syndrome: clinical study of 50 patients with matched normal controls. Bull Rheum Dis. 1977;28:928-31.
  • Podolecki T, Podolecki A, Hrycek A. Fibromyalgia: pathogenetic, diagnostic and therapeutic concerns. Pol Arch Med Wewn. 2009;119:157-61.
  • Stahl SM. Fibromyalgia-pathways and neurotransmitters. Hum Psychopharmacol. 2009;24:11-7.
  • .Jin H, Patil PM, Sharma A. Topical review: the enigma of fibromyalgia. J Oral Facial Pain Headache. 2014;28:107-18.
  • Mease P. Fibromyalgia syndrome: review of clinical presentation, pathogenesis, outcome measures, and treatment. J Rheumatol Suppl. 2005;75:6-21.
  • Fayed N, Andres E, Rojas G, Moreno S, Serrano-Blanco A, Roca M et al. Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study. Acta Psychiatr Scand. 2012;126:115-25.
  • Wolfe F, Symthe HA, Yunus MB, Bennet RM, Bombardier C, Goldenberg DL et al. The American College of Rheumatology 1990 criteria for the classification of the fibromyalgia: report of the multicenter criteria committee. Arthritis Rheum. 1990;33:160-72.
  • Bennett R, Friend R, Marcus D, Bernstein C, Han BK, Yachoui R et al. Criteria for the diagnosis of fibromyaljia: Validation of the modified 2010 preliminary ACR criteria and the development of alternative criteria. Arthritis Care Res (Hoboken). 2014;66:1364-73.
  • Fitzcharles MA, Shir Y, Ablin JN, Buskila D, Amital H, Henningsen P et al. Classification and clinical diagnosis of fibromyalgia syndrome: recommendations of recent evidence-based interdisciplinary guidelines. Evid Based Complement Alternat Med. 2013;2013:528952.
  • Belenguer R, Siso A, Ramos-Casals M. Fibromyalgia classification: are there different classes of patients? Rev Fac Cien Med Unıv Nac Cordoba. 2009;66:146-57.
  • Sarzi-Puttini P, Atzeni F, Di Franco M, Buskila D, Alciati A, Giacomelli C et al. Dysfunctional syndromes and fibromyalgia: a 2012 critical digest. Clin Exp Rheumatol. 2012;30:143-51.
  • Munguia-Izquerdo D, Legaz-Arrese A, Moliner-Urdiales D, Reverter-Masia J. Neuropsychological performance in patients with fibromyalgia syndrome: relation to pain and anxiety. Psicothema. 2008;20:427-3.
  • Schmidt-Wilcke T, Wood P, Lürding R. Cognitive impairment in patients suffering from fibromyalgia. An underestimated problem.Schmerz. 2010;24:46-53.
  • Periot-Nierga I, Hernandez-Ferrandiz M, Lozano-Gallego M, Vilalta-Franch J, Cruz-Reina Mdel M, Lopez-Pousa S. Cognitive profile in fibromyalgia. Comparison with a mild cognitive impairment group. Med Clin (Barc). 2009;133:91-4.
  • Dick BD, Verrier MJ, Harker KT, Rashiq S. Disruption of cognitive function in fibromyalgia syndrome. Pain. 2008;139:610-6.
  • Glass JM. Fibromyalgia and cognition.J Clin Psychiatry. 2008;69:20-4.
  • Katz RS, Heard AR, Millis M, Leavitt F. The prevalence and clinical impact of reported cognitive difficulties(fibrofog) in patients with rheumatic disease with and without fibromyalgia. J Clin Rheumatol. 2004;10:53-8.
  • Leavitt F, Katz RS, Mills M, Heard AR. Cognitive and dissociative manifestations in fibromyalgia. J Clin Rheumatol. 2002;8:77-84.
  • Tesio V, Torta DM, Colonna F, Leombruni P, Ghiggia A, Fusaro E et al. Are fibromyalgia patients cognitively impaired? Objective and subjective neuropsychological evidence.Artritis Care Res (Hoboken). 2014; doi: 10.1002/acr.22403.
  • Bertolucci PH, de Oliveira FF. Cognitive impairment in fibromyalgia. Curr Pain Headache Rep. 2013;17:344.
  • Folstein MF, Folstein SE, McHugh PR. ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. J Psyschiatr Res. 1975;12:189-98.
  • Rodrigez-Andreu J, Ibanez-Bosch R, Portero-Vazquez A, Masramon X, Rejas J, Galvez R. Cognitive impairment in patients with fibromyalgia syndrome as assessed by the mini-mental state examination. BMC Musculoskelet Disord. 2009;10:162.
  • Seo J, Kim SH, Kim YT, Song HJ, Lee JJ, Kim SH et al. Working memory impairment in fibromyalgia patients associated with altered frontoparietal memory network. PLoS One. 2012;7:e37808.
  • Kim SH, Kim SH, Kim SK, Nam EJ, Han SW, Lee SJ. Spatial versus verbal memory impairments in patients with fibromyalgia. Rheumatol Int. 2012;32:1135-42.
  • Gelonch O, Garolera M, Rossello L, Pifarre J. Cognitive dysfunction in fibromyalgia. Rev Neurol. 2013;56:573-88.
  • Duschek S, Werner NS, Winkelmann A, Wankner S. Implicit memory function in fibromyalgia syndrome. Behav Med. 2013;39:11-6.
  • Glass JM, Park DC. Cognitive dysfunction in fibromyalgia. Curr Rheumatol Rep. 2001;3:123-7.
  • WeiB S, Winkelmann A, Duschek S. Recognition of facially expressed emotions in patients with fibromyalgia syndrome. Behav Med. 2013;39:146-54.
  • Frange C, Hirotsu C, Hachul H, Araujo P, Tufik S, Andersen ML. Fibromyalgia and sleep in animal models: a current overview and future directions. Curr Pain Headache Rep. 2014;18:434.
  • Kleinman L, Mannix S, Arnold LM, Burbridge C, Howard K, McQuarrie K et al. Assesment of sleep in patients with fibromyalgia: qualitative development of the fibromyalgia sleep diary. Health Qual Life Outcomes. 2014;12:111.
  • Apairicio VA, Ortega FB, Carbonell-Baeza A, Camiletti D, Ruiz JR, Delgado-Fernandez M. Relationship of weight status with mental and physical health in female fibromyalgia patients. Obes Facts. 2011;4:443-8.
  • Arranz L, Canela MA, Rafecas M. Relationship between body mass index, fat mass and lean mass with SF-36 quality of life scores in a group of fibromyalgia patients. Rheumatol Int. 2012;32:3605-11.
  • Ursini F, Naty S, Grembiale RD. Fibromyalgia and obesity: the hidden link. Rheumatol Int. 2011;31:1403-8.
  • Arreghini M, Manzoni GM, Catelnuvo G, Santovito C, Capodaglio P. Impact of fibromyalgia on functioning in obese patients undergoing comprehensive rehabilitation. PLoS One. 2014;9:e91392.
  • Fava A, Plastino M, Cristiano D, Spano A, Cristofaro S, Opipari C et al. Insulin resistance possible risk factor for cognitive impairment in fibromialgic patients. Metab Brain Dis. 2013;28:619-27.
  • Braz Ade S, de Paula AP, Diniz Mde F, de Almeida RN. Non-pharmacological therapy and complementary and alternative medicine in fibromyalgia. Rev Bras Reumatol. 2011;51:269-82.
  • Henriksen M, Lund H, Christensen R, Jespersen A, Dreyer L, Bennet LM et al. Relationships between the fibromyalgia impact questionnaire, tender point count, and muscle strength in female patients with fibromyalgia: a cohort study. Arthritis Rheum. 2009;61:732-9.
  • Staud R, Robinson ME, Price DD. Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls. Pain. 2005;118:176-84.
  • Gonzalez Gonzalez J, Del Teso Rubio MD, Walino Paniagua CN, Criado-Alvarez JJ, Sanchez Holgado J. Symptomatic pain and fibromyalgia treatment through multidisciplinary approach for Primary Care. Reumatol Clin. 2014;pii:S1699-258X(14):00081-3.
  • Etnier JL, Karper WB, Gapin JI, Barella LA, Chang YK, Murphy KJ. Exercise, fibromyaljia, and fibrofog: a pilot study. J Phys Act Health. 2009;6:239-46.
  • Arnold LM. Strategies for managing fibromyalgia. Am J Med. 2009;122:31-43.
  • Lange M, Krohn-Grimberghe B, Petermann F. Effects of a cognitive-behavioral patient education on fibromyalgia: a controlled efficacy study. Z Rheumatol. 2011;70:324-31.
  • Jacopson SA, Simpson RG, Lubahn C, Hu C, Belden CM, Davis KJ et al. Characterization of fibromyalgia symptoms in patients 55-95 years old: a longitudinal study showing symptom persistence with suboptimal treatment. Aging Clin Exp Res. 2014; doi: 10.1007/s405520-014- 0238-7.
  • Cadenas-Sanchez C, Ruiz-Ruiz J. Effect of a physical activity program in patients with fibromyalgia: A systematic review. Med Clin (Barc). 2014. doi: 10.1016/j.medcli.2013.12.010.
  • Sauer K, Kemper C, Glaeske G. Fibromyalgia syndrome: prevalence, pharmacological and non- pharmacological interventions in outpatient health care. An analysis of statutory health insurance data.Joint Bone Spine. 2011;78:80-4.
Toplam 48 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derleme
Yazarlar

Tuba Koca

Yayımlanma Tarihi 17 Kasım 2014
Yayımlandığı Sayı Yıl 2015 Cilt: 24 Sayı: 1

Kaynak Göster

AMA Koca T. Fibromiyaljide Kognitif Disfonksiyon. aktd. Kasım 2014;24(1):105-118. doi:10.17827/aktd.07534