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Complete scintigraphic resolution of a bone metastasis after androgen-deprivation therapy

Yıl 2019, Cilt: 3 Sayı: 12, 898 - 899, 03.12.2019
https://doi.org/10.28982/josam.598062

Öz

99mTc-methylene diphosphonate (MDP) whole body bone scintigraphy is a frequently used imaging method for the evaluation of the bone metastases of prostate cancer. Nuclear medicine imaging modalities are very valuable in terms of functional assessment and treatment response assessment of the malign lesions that cannot be detected by anatomic imaging methods. However, it is known that some scintigraphic studies may have a relatively limited role in defining resolution and anatomical details of the lesion, compared to some radiological imaging modalities. Androgen-deprivation therapy (ADT) alone is rarely effective for the treatment of bone metastases, on that account combined systemic therapies are often preferred. Here we present a rare case of prostate cancer with radiologically undetectable bone metastasis evident on scintigraphy that has disappeared after 18 months of ADT.

Kaynakça

  • 1. Van den Wyngaert T, Strobel K, Kampen WU, Van den Wyngaert T, Strobel K, Kampen WU, et al. The EANM practice guidelines for bone scintigraphy. Eur J Nucl Med Mol Imaging. 2016;43:1723-38.
  • 2. Bozkurt MF, Dede Z, Burak Z, Ak I, Bekis R, Degirmenci B, et al. Procedure Guideline For Bone Scintigraphy. Turk J Nucl Med. 2001;10:97-102.
  • 3. Kölükçü E, Beyhan M, Atılgan D. Factors affecting complications of transrectal ultrasound-guided prostate biopsy: A cohort study with 403 patients in a single center. J Surg Med. 2019;3(2):183-6.
  • 4. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
  • 5. O'Sullivan JM, Norman AR, Cook GJ, Fisher C, Dearnaley DP. Broadening the criteria for avoiding staging bone scans in prostate cancer: a retrospective study of patients at the Royal Marsden Hospital. BJU Int. 2003;92:685-9.
  • 6. Huggins C, Hodges CV. Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res. 1941;1:293-7.
  • 7. Cornford P, Bellmunt J, Bolla M, Briers E, De Santis M, Gross T, et al. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part II: Treatment of Relapsing, Metastatic, and Castration-Resistant Prostate Cancer. Eur Urol. 2017;71:630-42.
  • 8. Mcleod DG, Iversen P, See WA, Morris T, Armstrong J, Wirth MP, et al. Bicalutamide 150 mg plus standard care vs standard care alone for early prostate cancer. BJU International. 2006;97:247-54.

Androjen-Deprivasyon tedavisi ile regrese olan kemik metastazının sintigrafik değerlendirmesi

Yıl 2019, Cilt: 3 Sayı: 12, 898 - 899, 03.12.2019
https://doi.org/10.28982/josam.598062

Öz

99mTc-metilen difosfonat (MDP) tüm vücut kemik sintigrafisi prostat kanserinin kemik metastazlarını değerlendirmede sıklıkla kullanılmaktadır. Anatomik görüntüleme yöntemleri ile saptanamayan malign lezyonların fonksiyonel olarak izlenebilmesi ve tedaviye yanıtının değerlendirilebilmesi açısından nükleer tıp tetkikleri çok değerlidir. Bununla birlikte sintigrafik yöntemlerin rezolüsyon ve anatomik detayları belirlemede bazı radyolojik tetkiklere göre sınırlı olabildiği bilinmektedir. Kemik metastazlarının tedavisinde sıklıkla kombine sistemik tedaviler tercih edilmekte olup, androjen-deprivasyon tedavisi (ADT) tek başına nadiren etkilidir. Burada bilgisayarlı tomografi ile saptanamayan, 18 ay ADT ile regrese olan kemik metastazlı nadir prostat kanserli bir olguyu sunuyoruz.

Kaynakça

  • 1. Van den Wyngaert T, Strobel K, Kampen WU, Van den Wyngaert T, Strobel K, Kampen WU, et al. The EANM practice guidelines for bone scintigraphy. Eur J Nucl Med Mol Imaging. 2016;43:1723-38.
  • 2. Bozkurt MF, Dede Z, Burak Z, Ak I, Bekis R, Degirmenci B, et al. Procedure Guideline For Bone Scintigraphy. Turk J Nucl Med. 2001;10:97-102.
  • 3. Kölükçü E, Beyhan M, Atılgan D. Factors affecting complications of transrectal ultrasound-guided prostate biopsy: A cohort study with 403 patients in a single center. J Surg Med. 2019;3(2):183-6.
  • 4. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
  • 5. O'Sullivan JM, Norman AR, Cook GJ, Fisher C, Dearnaley DP. Broadening the criteria for avoiding staging bone scans in prostate cancer: a retrospective study of patients at the Royal Marsden Hospital. BJU Int. 2003;92:685-9.
  • 6. Huggins C, Hodges CV. Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res. 1941;1:293-7.
  • 7. Cornford P, Bellmunt J, Bolla M, Briers E, De Santis M, Gross T, et al. EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part II: Treatment of Relapsing, Metastatic, and Castration-Resistant Prostate Cancer. Eur Urol. 2017;71:630-42.
  • 8. Mcleod DG, Iversen P, See WA, Morris T, Armstrong J, Wirth MP, et al. Bicalutamide 150 mg plus standard care vs standard care alone for early prostate cancer. BJU International. 2006;97:247-54.
Toplam 8 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Radyoloji ve Organ Görüntüleme
Bölüm Olgu sunumu
Yazarlar

Derya Çayır 0000-0002-7756-3210

Mehmet Bozkurt 0000-0002-8325-5249

Salih Sinan Gültekin Bu kişi benim 0000-0003-2458-3530

Aynur Turan 0000-0001-6654-3129

Yayımlanma Tarihi 3 Aralık 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 3 Sayı: 12

Kaynak Göster

APA Çayır, D., Bozkurt, M., Gültekin, S. S., Turan, A. (2019). Complete scintigraphic resolution of a bone metastasis after androgen-deprivation therapy. Journal of Surgery and Medicine, 3(12), 898-899. https://doi.org/10.28982/josam.598062
AMA Çayır D, Bozkurt M, Gültekin SS, Turan A. Complete scintigraphic resolution of a bone metastasis after androgen-deprivation therapy. J Surg Med. Aralık 2019;3(12):898-899. doi:10.28982/josam.598062
Chicago Çayır, Derya, Mehmet Bozkurt, Salih Sinan Gültekin, ve Aynur Turan. “Complete Scintigraphic Resolution of a Bone Metastasis After Androgen-Deprivation Therapy”. Journal of Surgery and Medicine 3, sy. 12 (Aralık 2019): 898-99. https://doi.org/10.28982/josam.598062.
EndNote Çayır D, Bozkurt M, Gültekin SS, Turan A (01 Aralık 2019) Complete scintigraphic resolution of a bone metastasis after androgen-deprivation therapy. Journal of Surgery and Medicine 3 12 898–899.
IEEE D. Çayır, M. Bozkurt, S. S. Gültekin, ve A. Turan, “Complete scintigraphic resolution of a bone metastasis after androgen-deprivation therapy”, J Surg Med, c. 3, sy. 12, ss. 898–899, 2019, doi: 10.28982/josam.598062.
ISNAD Çayır, Derya vd. “Complete Scintigraphic Resolution of a Bone Metastasis After Androgen-Deprivation Therapy”. Journal of Surgery and Medicine 3/12 (Aralık 2019), 898-899. https://doi.org/10.28982/josam.598062.
JAMA Çayır D, Bozkurt M, Gültekin SS, Turan A. Complete scintigraphic resolution of a bone metastasis after androgen-deprivation therapy. J Surg Med. 2019;3:898–899.
MLA Çayır, Derya vd. “Complete Scintigraphic Resolution of a Bone Metastasis After Androgen-Deprivation Therapy”. Journal of Surgery and Medicine, c. 3, sy. 12, 2019, ss. 898-9, doi:10.28982/josam.598062.
Vancouver Çayır D, Bozkurt M, Gültekin SS, Turan A. Complete scintigraphic resolution of a bone metastasis after androgen-deprivation therapy. J Surg Med. 2019;3(12):898-9.